副教授、副研究员
许志刚
发布时间: 2017-10-12 20:47:45   作者:本站编辑   来源: 本站原创   浏览次数:

教师简介:

                                                                                  

姓名:许志刚

职称:副教授

所属系:洁净能源与先进材料研究院  

邮箱:zgxu@swu.edu.cn   课题组网站   English version

电话:18323269359

学习及工作经历

2008.09-2013.06 兰州大学   化学化工学院        博士

2013.07-2015.07 新加坡南洋理工大学   化学与生物工程学院  Research   Fellow

2015.07-至今   西南大学   材料与能源学部   副教授,硕士生导师

 

主要研究领域、方向

主要研究领域为纳米生物材料,开展了智能型药物递送系统、高灵敏分子荧光探针和靶向小分子药物的合成及其性能研究。

 

研究成果(200字以内)

截止目前,在Chemical Communication,Acta Biomaterialia,Biomacromolecules,Nanoscale等国际著名刊物上发表SCI论文60余篇,研究论文累计被他人正面引用达1000余次,目前个人H影响因子20,申请国家发明专利10余项,授权1项。成果曾获2014年度甘肃省高校科技进步奖一等奖(本人排名第三),担任重庆功能材料学会理事。

荣誉&获奖

1、甘肃省高校科技进步奖 一等奖   题目:《新型药物载体的合成与研究》,2014(张海霞,沈剑敏,许志刚,陈桐)

主讲课程

纳米生物学(研究生)、生物材料学(研究生)和靶向药物与输送(研究生)

 

承担科研、教改和教学质量工程项目

1、GSH/pH响应型星形聚合物前药的设计、构建及靶向抗肿瘤研究,国家自然科学基金(51703187),2018.01-2020.12,22万,项目负责人

2、激活型单分子胶束药物载体的设计及抗肿瘤性能研究,重庆市基础研究与前沿探索项目(cstc2018jcyjAX0104),2018.07-2021.06,10万,项目负责人

3. 星形聚合物荧光探针的设计、合成及在肿瘤早期诊断中的应用,四川省应用基础研究计划(面上项目,2018JY0392),2018.07-2020.06,10万,项目负责人

4、pH敏感型星形单分子聚合物的构建及其在肿瘤诊断与治疗中的应用,重庆市基础与前沿研究计划项目(cstc2016jcyjA0078),2016.07-2019.06,5万,项目负责人

5、智能型小分子药物传递系统的设计、合成及其在癌症治疗中的应用研究,中央高校基本科研业务费一般项目(XDJK2016C004),2016.01-2017.12,5万,项目负责人

6、西南大学人才引进基金(SWU115058),2016.01-2018.12,20万,项目负责人

代表性论著:

1.     Xiaoqian Ma, Xiaoxiao Shi, Shuang Bai,   Jianjian Zhang, Meili Hou, Tian Zhang, Bao-sheng Li, Peng Xue, Yuejun Kang*, Zhigang   Xu*, Water-soluble   Fluorescent Unimolecular Micelles: Ultra-small size, tunable fluorescence   emission from visible to NIR region and enhanced biocompatibility for in vitro and in vivo bioimaging, Chem.   Commun., 2018, 54, 6252-6255. (IF2017   =   6.290, Front cover)

2.     Meili Hou, Yong-E Gao, Xiaoxiao Shi, Shuang Bai, Xiaoqian Ma, Baosheng   Li, Bo Xiao, Peng Xue, Yuejun Kang*, ZhigangXu*,   Methotrexate-based amphiphilic prodrug nanoaggregates for co-administration   of multiple therapeutics and synergistic cancer therapy. Acta Biomaterialia, 2018,   77, 228-239 (IF2017   =   6.383)

3.     Shuang Bai, Xiaoli Zhang, Xiaoqian Ma, Jiuncun Chen, Qiubing Chen,   Xiaoxiao Shi, Meili Hou, Peng Xue, Yuejun Kang*, Zhigang Xu*, Acid-active supramolecular anticancer   nanoparticles based on cyclodextrin polyrotaxanes damaging both mitochondria   and nuclei of tumor cells. Biomaterials   Science, 2018, 6, 3126-3138. (IF2017   = 5.831, Front cover).           

4.     Xiaoxiao Shi, Shuang Bai, Cangjie Yang, Xiaoqian Ma, Meili Hou, Jiucun   Chen, Peng Xue, Chang Ming Li, Yuejun Kang*, Zhigang Xu*, Improving the carrier stability and drug   loading of unimolecular micelle-based nanotherapeutics for acid-activated   drug delivery and enhanced antitumor therapy. Journal of Materials Chemistry B, 2018, 6, 5549-5561. (IF2017 = 4.776,   Back cover)

5.     Shuang Bai, Meili Hou, Xiaoxiao Shi, Jiuncun   Chen, Xiaoqian Ma, Yong-E Gao, Yajun Wang, Peng Xue, Yuejun Kang*, Zhigang   Xu*,   Reduction-active polymeric prodrug micelles based on α-cyclodextrin   polyrotaxanes for triggered drug release and enhanced cancer therapy, Carbohydrate Polymers, 2018, 193, 153-162. (IF2017   =   5.158)

6.     Shuang Bai, Yong-E Gao, Xiaoqian Ma, Xiaoxiao   Shi, Meili Hou, Peng Xue*, Yuejun Kang*, Zhigang Xu*, Reduction stimuli-responsive unimolecular   polymeric prodrug based on amphiphilic dextran-framework for antitumor drug   delivery, Carbohydrate Polymers, Carbohydrate   Polymers, 2018, 182, 235-244. (IF2017   =   5.158)

7.     Xiaoxiao Shi, Xiaoqian Ma, Meili Hou, Yong-E Gao, Shuang Bai, Bo Xiao, Peng Xue, Yuejun   Kang, Zhigang Xu*, Chang   Ming Li, pH-responsive unimolecular micelles based on amphiphilic star-like   copolymers with high drug loading for effective drug delivery and cellular   imaging, Journal of Materials Chemistry   B, 2017, 5, 6847-6859. (IF2017   =   4.776)

8.     Xiaoxiao Shi, Meili Hou, Shuang Bai, Xiaoqian Ma, Yong-E   Gao, Bo Xiao, Peng Xue, Yuejun Kang*,   Zhigang Xu*, Chang Ming Li,   Acid-Activatable Theranostic Unimolecular Micelles Composed of Amphiphilic   Star-like Polymeric Prodrug with High Drug Loading for Enhanced Cancer   Therapy, Molecular Pharmaceutics, 2017, 14, 4032-4041. (IF2017   = 4.556) 

9.     Meili Hou, Peng Xue, Yong-E Gao, Xiaoqian Ma, Shuang Bai, Yuejun   Kang*, Zhigang Xu*, Gemcitabine–camptothecin   conjugates: a hybrid prodrug for controlled drug release and synergistic   therapeutics, Biomaterials Science   , 2017, 5, 1889-1897. (IF2017   = 5.831).

10. Zhigang Xu, Shiying Liu,   Hui Liu, Cangjie Yang, Yuejun Kang and Mingfeng Wang*, Unimolecular micelles of amphiphilic   cyclodextrin-core star-like block   copolymers for anticancer drug delivery, Chemical Communication,   2015, 51, 15768-15771. (IF2017   =   6.290)

 

专利

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