【副教授】肖波
发布时间:2012-10-21 09:02:40     作者:    浏览次数: 次

肖波,博士,副教授,硕士生导师。

 

学习与工作经历:

2014.09至今      西南大学   洁净能源与先进材料研究院    副教授

2011.092014.09 美国乔治亚州立大学生物医学科学研究院(合作导师:Didier Merlin 教授)      博士后

2008.092011.07 华中科技大学 生物医学工程系(导师:张胜民 教授)         博士

2006.092008.07 华中科技大学 生物医学工程系(导师:张胜民/万影 教授)    硕士

2002.092006.07   西南大学     生物工程系  (导师:潘国庆 副教授)         学士

 

联系方式:hustboxiao@gmail.com

 

课题组网址:http://bxiao.polymer.cn/

 

研究领域:

1.   结肠疾病治疗相关口服给药系统:基于结肠疾病(结肠炎和结肠癌)的致病分子机理,选用合适药物(siRNA、化学药物),设计并制备纳米粒子、微米粒子或水凝胶等口服给药系统,以达到治疗或预防结肠疾病的目的;

2.  人工皮肤支架材料:选用具有优良生物相容性的天然高分子及其衍生物(如壳聚糖、丝素、胶原、透明质酸等)或/和合成高分子(如PLGAPCL等)材料,与细胞、细胞因子、药物等结合,制备纳米纤维薄膜、水凝胶等,以达到创伤修复的目的。

 

主持项目(PI:

1.    国家自然科学基金青年项目,靶向共载CD98-siRNA和姜黄素纳米粒子/水凝胶系统的构建及其口服协同治疗溃疡性结肠炎的机制研究,经费:24万,2016.01-2018.12

2.   国家自然科学基金面上项目,口服靶向纳米粒子介导CD98沉默提高结肠癌化疗敏感性及其分子机制研究,经费:68.4万,2016.01-2019.12

3.    教育部留学回国人员科研启动基金,3万,2016.01-2018.12

4.   西南大学人才引进基金,逆转结肠癌多药耐受和促进细胞内吞的表面双功能化纳米粒子研究,经费:25万,2015.012017.12

5.    美国心脏协会博士后研究基金(13POST16400004),“Nanoparticles: Therapeutic Approach in Atherosclerosis”,经费:9.3万美元,2013.062014.12

 

招生:

本课题组研究领域具有多学科交叉特点,热忱欢迎有志于从事科研工作的高分子化学、药学、生物医学和材料学等专业的同学报考硕士研究生。有疑问请随时email联系。

 

代表性学术论文(近5年):

1. Xiao B.*, Zhang Z, Viennois E, Kang Y, Zhang M, Han MK, Chen J, Merlin D. Combination Therapy for Ulcerative Colitis: Orally Targeted Nanoparticles Prevent Mucosal Damage and Relieve Inflammation. Theranostics 2016;6:2250.IF = 8.8

2. Xiao B.*, Xu Z, Viennois E, Zhang Y, Zhang Z, Zhang M, Han MK, Kang Y, Merlin D. Orally Targeted Delivery of Tripeptide KPV via Hyaluronic Acid-functionalized Nanoparticles Efficiently Alleviates Ulcerative Colitis. Molecular Therapy 2017;25:1.Cell子刊,IF = 6.9

3. Ma L. (马莉君), Xiao B.*, Merlin D. Nanoparticle-mediated co-delivery of chemotherapeutic agent and siRNA for combination cancer therapy. Expert Opinion on Drug Delivery 201714:65.IF = 5.4

4. Xiao B.*, Ma P, Viennois E, Merlin D. Urocanic acid-modified chitosan nanoparticles can confer anti-inflammatory effect by delivering CD98 siRNA to macrophages. Colloids and Surfaces B: Biointerfaces 2016;143:186.IF = 3.9

5. Xiao B.*, Ma P, Ma L, Chen Q, Si X, Walter L, Merlin D. Effects of tripolyphosphate on cellular uptake and RNA interference efficiency of chitosan-based nanoparticles in Raw 264.7 macrophages. Journal of Colloid and Interface Science 2017;490:520.IF = 3.7

6.  Si XY(司笑莹), Merlin D, Xiao B*. Recent advances in orally administered cell-specific nanotherapeutics for inflammatory bowel disease. World Journal of Gastroenterology 2016;22:7718.IF = 2.7

7.  Xiao B.*, Zhang M., Viennois E., Zhang Y., Wei N., Baker M.T., Jung Y., Merlin D. Inhibition of MDR1 gene expression and enhancing cellular uptake for effective colon cancer treatment using dual-surface-functionalized nanoparticles. Biomaterials, 48:147-160, 2015. 生物材料领域排名第一的杂志,IF = 8.3

8. Xiao B.*, Han M. K., Viennois E., Wang L., Zhang M., Si X., Merlin D. Hyaluronic acid-functionalized polymeric nanoparticles for colon cancer-targeted combination chemotherapy. Nanoscale. 2015;7:17745.  (IF =7.7 

9. Xiao B.*, Si X.Y., Han M. K., Viennois E., Zhang M. Z., Merlin D. Co-delivery of camptothecin and curcumin by cationic polymeric nanoparticles for synergistic colon cancer combination chemotherapy. Journal of Materials Chemistry B.2015, 3:7724-7733. IF = 4.8

10. Xiao B.*, Si X, Zhang M, Merlin D. Oral administration of pH-sensitive curcumin-loaded microparticles for ulcerative colitis therapy. Colloids Surf B: Biointerfaces. 2015, 135: 379-385. IF = 3.9

11.  Xiao B.*, Laroui H., Viennois E., Ayyadurai S., Charania M.A., Zhang Y., Zhang Z., Baker M.T., Zhang B., Gewirtz A.T., Merlin D.. Nanoparticles with surface antibody against CD98 and carrying CD98 small interfering RNA reduce colitis in mice. Gastroenterology, 146(5):1289-1300, 2014. 胃肠道与肝病学领域排名第一的杂志,IF = 18.1

12. Xiao B.*, Yang Y., Viennois E., Zhang Y., Ayyadurai S., Baker M.T., Laroui H., Merlin D.. Glycoprotein CD98 as a receptor for colitis-targeted delivery of nanoparticles. Journal of Materials Chemistry B, 2(11): 1499-508, 2014. IF = 4.8

13.  Xiao B.*, Laroui H., Ayyadurai H., Viennois E., Charania M.A., Zhang Y., Merlin D.. Mannosylated bioreducible nanoparticle-mediated macrophage-specic TNF-α RNA interference for IBD therapy. Biomaterials, 34(30):7471-82, 2013. 生物材料领域排名第一的杂志,IF = 8.3

14.  Xiao B.*, Merlin D. Oral colon-specific therapeutic approaches toward treatment of inflammatory bowel disease. Expert Opinion on Drug Delivery, 9(11):1393-407, 2012. IF = 5.4

15. Xiao B., Wang X.Y., Qiu Z.Y., Ma J., Zhou L., Wan Y.*, Zhang S.M*. A dual-functionally modified chitosan derivative for efficient liver-targeted gene delivery. Journal of Biomedical Materials Research A, 101(7):1888-97, 2013.

16. Xiao B., Wan Y., Wang X.Y., Zha Q.C., Liu H.M., Qiu Z.Y., Zhang S.M.*. Synthesis and characterization of N-(2-hydroxy)propyl-3-trimethyl ammonium chitosan chloride for potential application in gene delivery. Colloids Surface B: Biointerfaces, 91:168-74, 2012.

 

申请专利:

1. Merlin D., Xiao B. Compositions and methods employing CD98 inhibitors and curcumin. (美国专利, Application number: 62/400,947).

2. 肖波、马盼盼、陈秋冰.一种负载抗肿瘤药物串珠状纳米纤维膜的制备方法. (中国专利,申请号:2016112600778).

3. 肖波、司笑莹、陈秋冰. 一种载药多孔纳米粒子的制备方法. (中国专利,申请号:201710005561.4)

4. 肖波、司笑莹. 一种抑制多药耐受基因表达的靶向抗肿瘤纳米药物. (中国专利,申请号:2016112623619)

5. 肖波、司笑莹、马莉君. 一种靶向结肠炎组织的三肽修饰的纳米粒子的制备方法. (中国专利,申请号:201611257241.X)

6. 肖波、司笑莹. 一种溃疡性结肠炎组织靶向分子及其应用. (中国专利,申请号:2016101043573)

7. Merlin D., Xiao B., Laroui H.. Constructs for diagnosing and treating inflammatory bowel diseases and colon cancer. (美国专利, Application number: 14/401,957).

8. 张胜民、贾希亮、肖波、仇志烨一种用于制备医用创伤敷料的抗菌水凝胶材料及其制备方法. (中国专利,专利号:201110276481).

9. 张胜民、肖波、刘艺群、万影一种高取代度精氨酸-壳聚糖及其制备方法和应用. (中国专利,申请号:200910063587.X).

 

学术奖励:

2016年,入选重庆市高等学校青年骨干教师资助计划

2013年,获得美国心脏协会博士后奖学金

2013年,获得美国消化疾病周(Digestive Disease Week,为全球消化疾病学界规模最大、学术水平最高、享有最高声望的国际会议)的杰出海报“Poster of Distinction”

 

学术兼职:

曾多次应邀为Nature Communications, Gastroenterology, Biomaterials, Theranostics, Clinical Cancer Research, Advanced Healthcare Materials, Chemical Communications, Acta Biomaterialia, Nanoscale, Nanomedicine (lond), Scientific Reports, Mol. Pharm, Int. J. Nanomedicine等国际权威杂志审稿。